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After completing training in Physics and Atmospheric Sciences in 2003, Tomoko Matsuo invested time to build expertise in statistics and data assimilation. She has received unique training in statistics as part of an NSF program to build collaborative research and training between statistics and the geosciences at NCAR's Institute of Mathematics Applied to Geosciences.

Matsuo joined Smead Aerospace Engineering Sciences as a faculty member in 2017 and earned an NSF CAREER Award in 2019. She has developed original and independent research programs centered on data assimilation of remotely sensed and in-situ data of the Earth's upper atmosphere and near-Earth space. Because of the interdisciplinary nature of data assimilation research, she collaborates widely across disciplinary boundaries with space physicists, atmospheric scientists, engineers, and statisticians.